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KMID : 0356420000180010055
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Journal of Korean Andrology
2000 Volume.18 No. 1 p.55 ~ p.58
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Altered Contents of Smooth Muscle and Collagen in Corpus Cavernosum in Patients with Erectile Dysfunction
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Park Hyung-Keun
Hong Jun-Hyuk
Park Jong-Yeon
Ahn Tai-Young
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Abstract
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Purpose: Cavernosal smooth-muscle relaxation is essential for penile erection.
Reduction or dysfunction of the muscle fibers can be related to impaired relaxation of
cavernosal smooth muscle. Our study was aimed at seeing the changes in penile smooth
muscle and collagen tissue in patients with erectile dysfunction.
Patients and Methods: Twelve impotent patients (study group; mean age 56.3 years)
and five penile cancer patients (control group; mean age 57.6 years) were included. The
cause of the impotence was peyronie’s diease, diabetes, and unknown in four patients
each. Cavernosal tissues were obtained at the time of penile prosthesis implantation and
fixed immediately in 10% Formalin. After staining with Masson’s trichrome, analysis of
smooth muscle fibers was performed suing ImagePro.
Results: The smooth muscle ratio was 75.1±10.6% (SD) in the control group, 37.7±
12.2 in Peyronie’s disease, 37.1±18.4% in the patients with diabetes, and 52.2±10.6% in
the group with no known underlying disease. There was a statistically significant
difference in the smooth muscle ratio between the study and control group, but among
the study groups, no significant difference was noted.
Conclusions: Altered content of smooth muscle may contribute to the pathophysiology
of erectile dysfunction
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KEYWORD
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Collagen, Corpus cavemosum, Erectile dysfunction, Penis,
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